Senior Development Analyst/Development Scientist I

Company OverviewImClone Systems is dedicated to developing and commercializing novel therapeutic products in the field of oncology. Our efforts have resulted in a broad spectrum of innovative product candidates with potential application in multiple tumor types. As a member of the oncology community, we are committed to providing treatments to meet the unmet needs of cancer patients. To fulfill this commitment, ImClone Systems fosters integration of the principles of teamwork and scientific integrity into all facets of the Company's activities. We believe that these values will benefit patients, physicians, and our employees while creating value for our shareholders. HistoryThe Company was founded in 1984 and in 1986, opened its laboratories at 180 Varick Street in New York City. In its early years, the Company focused on immunology-based diagnostics and infectious disease vaccines. This focus resulted in two FDA approved diagnostics and several vaccine research programs, all of which have been licensed to pharmaceutical companies. During the early nineties, the Company's focus shifted from diagnostics and infectious disease to the development of a pipeline of innovative, biologic compounds in the area of oncology. From this pipeline, three investigational monoclonal antibodies are being evaluated in various stages of clinical development. OperationsImClone Systems operates in two locations - its corporate and scientific headquarters at 180 Varick Street in New York City, which houses the Company's research and executive offices, and its campus in Branchburg, New Jersey. The Branchburg facility is home to the manufacturing, product development, finance, clinical, regulatory and quality assurance and commercial operations departments. Bioanalytical Science Department is seeking an outstanding candidate to perform cGMP-regulated assays and to develop sensitive protein characterization assays using state-of-the-art analytical instrumentation. Candidate must have strong background knowledge of protein chemistry and hands-on experience and knowledge in protein characterization, using HPLC and mass spectrometry. Successful candidate will focus on the biochemical characterization of therapeutic antibodies in all stages of development, developing techniques and executing cGMP-regulated analytical assays. Candidate must be highly self-motivated, team-oriented, and goal-oriented with effective communication and interpersonal skills. Candidate will show record to demonstrate the willingness and ability to work as part of a larger multidisciplinary team of scientists.The essential duties and responsibilities are (but not limited to):1. Perform characterization analyses of monoclonal antibodies.2. Develop and qualify new or existing HPLC or 2D-LC and LC/MS based characterization methods.3. Develop and qualify cIEF method platform and assist tech transfer to QC.4. Characterize monoclonal antibodies using size exclusion chromatography with multiangle laser light scattering (MALLS) and reflective index (RI) detectors.5. Contribute to technical research reports, validation reports, and SOPs.6. Perform and follow cGMP regulatory guidance.7. Collaborate and support other groups and departments. Perform routine lab maintenance. 1. B.S., M.S. or Ph.D. in Biochemistry, Chemistry, or relevant disciplines. 2. B.S. (3+ yr.), M.S. (1+ yr), Ph.D. (0+ yr) of experience in state-of-the-art analytical techniques relevant to protein/glycoprotein characterization.3. Knowledge and/or hands-on experiences in cIEF, SDS-PAGE, HPLC and mass spectrometry for protein and peptide analysis.4. Knowledge and/or hands-on experience in biophysical characterization of protein is a plus.5. Strong organization and communication skills and effective interpersonal skills.6. Ability to learn new technologies and solve problems.7. Ability to work independently and in a team-oriented environment. 8. Ability to follow instructions and be attentive to details. RESPOND HERE! Respond immediately by accessing the following dedicated online response form which will allow you to cut and paste your resume. This form will go directly and immediately to the hiring authority for this position. Access the online response form at: http://sh.webhire.com/servlet/resp/rf?jobid=2253895&boardid=749