Scientist II, Chemical Engineer

Scientist II, Chemical Engineer Department/Division: Engineering Job Type: Full Time Company: Vertex Pharmaceuticals, Inc. Location: Cambridge, MA 02139 Job Reference Id: 202BR   Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company's strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex's product pipeline is focused on viral diseases, inflammation, autoimmune diseases, cancer, pain and bacterial infection. Vertex is seeking a talented individual to join our Chemical Development group in Cambridge, MA. Chemical Engineering at Vertex plays a vital role in bridging the gap between new pharmaceutical discoveries and commercial products. Engineers at Vertex work in multidisciplinary scientific teams to bring basic medical discoveries to patients and physicians by applying fundamental chemistry and chemical engineering principles to new products, processes, and development technologies. The successful candidate will be a highly productive, results-oriented individual, able to generate and implement original ideas and solutions that contribute materially to the success and development of drug substance candidates. Strong communication, organization, and planning skills and a high level of technical aptitude and creativity are required for success in this positionKey Responsibilities for this role include, but are not limited to:- Supporting drug substance process development via laboratory development, pilot plant scale-up, drug supply preparation, and technology transfer to third party manufacturing facilities- Defining, developing, and demonstrating commercially viable, multi-step, organic syntheses for the manufacture of small-molecule advanced intermediates and active pharmaceutical ingredients.- Providing leadership in the identification, development, and deployment of new instrumentation and automation technologies to support drug substance process development. Specific areas of focus include: reaction engineering/catalysis, separations, crystallization, physical property measurement, engineering unit operations, and chemical analysis.- Managing the transfer of bench-scale chemical processes to third party manufacturing facilitiesQualifications- A Ph.D. degree with 3+ years of academic, post-doctoral or pharmaceutical industry experience; an MS degree with 5+ years of pharmaceutical industry experience; or a BS degree with 8+ years of pharmaceutical industry experience. Degrees with a life science concentration required, with a preference for concentrations in chemical engineering or chemistry- A demonstrated understanding and working knowledge of chemistry and chemical engineering fundamentals; advanced technical knowledge and experience in API process development, process scale-up, troubleshooting, and optimization; applied kinetics, thermodynamics, and transport fundamentals; as well as familiarity with modern laboratory instrumentation (HPLC, GC, FTIR, Raman, FBRM, DSC, TGA, XRPD, etc), automation tools, and laboratory/plant implementation of PAT- Experience with modeling complex, physicochemical systems; data analysis; statistical design of experiments; QbD concepts, and fluency with common physical property and process modeling tools (Aspen, Dynochem, Matlab, etc.)- A track record of successful laboratory and pilot-scale development in the areas of reaction engineering, catalysis, crystallization, separation technologies, drying, and micronization- The ability to successfully interact, lead, and collaborate within an interdisciplinary team environment comprised of organic, physical, and analytical chemists; project team members; and manufacturing personnel- Experience with the management of external scientific activities and CRO/CMO relationships- Proven communication (verbal and written) and interpersonal skills Vertex Pharmaceuticals Inc., is an EQUAL OPPORTUNITY EMPLOYER. APPLY NOW