Research Investigator, Cell-Based Assays - Muscle Disease

Novartis Institutes for BioMedical Research is Novartis' global research organization and is committed to discovering innovative medicines that cure disease and improve human health. By conducting more relevant and predictable drug discovery that can yield new and better medicines for patients, Novartis Institutes for BioMedical Research is redefining drug discovery in the post-genomic era. Over the past four years, Novartis Pharmaceuticals has had the greatest number of new molecular entities approved by the US FDA. With its broad focus on diseases for which there is a need for better medical therapies, and with over 3,000 talented, dedicated research scientists worldwide, Novartis Institutes for BioMedical Research is well-positioned to ensure Novartis maintains its strong pipeline and highly successful track record in new drug discovery. Novartis Institutes has sites in Cambridge, Massachusetts (headquarters); Basel, Switzerland; Horsham, UK; East Hanover, NJ; and Emeryville, California. Novartis Institutes' Cambridge facilities encompass 950,000 square feet of laboratory and office space. Research in cardiovascular disease, oncology, infectious disease, diabetes, ophthalmology and muscle disease is headquartered in Cambridge. In addition, Cambridge is home to the following platform technologies: Global Discovery Chemistry, Functional Genomics, Developmental & Molecular Pathways, and Models of Disease Center.In order to attract and develop an exceptionally talented and committed staff, Novartis Institutes for BioMedical Research offers an innovative and comprehensive benefits package, including healthcare, insurance, savings, retirement, and work/life benefits.Job Description The successful candidate will lead a project focused on using cell-based assays to investigate and screen targets involved in skeletal muscle disease. The candidate should have experience in working with primary and established cell lines (preferably differentiated muscle cell lines, but this is not mandatory), as well as project and people management experience. It would be helpful to have a sound foundation in the area of skeltal muscle biology, but what is at least required is strong cell biology skills, and knowledge of assays such as reporter gene assays, biochemistry assays such as protein pull-downs, etc. Also some molecular biology experience would be very helpful, including vector construction, and experience in trasnsfecting or infecting cells with such constructs. Novartis Institutes for BioMedical Research is an equal opportunity employer committed to embracing and leveraging diverse backgrounds. M/F/D/V Job ID: 41687BR