Fellow - Biochemical & Molecular Toxicology

Novartis Institutes for BioMedical Research is Novartis' global research organization and is committed to discovering innovative medicines that cure disease and improve human health. By conducting more relevant and predictable drug discovery that can yield new and better medicines for patients, Novartis Institutes for BioMedical Research is redefining drug discovery in the post-genomic era. Over the past four years, Novartis Pharmaceuticals has had the greatest number of new molecular entities approved by the US FDA. With its broad focus on diseases for which there is a need for better medical therapies, and with over 3,000 talented, dedicated research scientists worldwide, Novartis Institutes for BioMedical Research is well-positioned to ensure Novartis maintains its strong pipeline and highly successful track record in new drug discovery. Novartis Institutes has sites in Cambridge, Massachusetts (headquarters); Basel, Switzerland; Horsham, UK; East Hanover, NJ; and Emeryville, California. Novartis Institutes' Cambridge facilities encompass 950,000 square feet of laboratory and office space. Research in cardiovascular disease, oncology, infectious disease, diabetes, ophthalmology and muscle disease is headquartered in Cambridge. In addition, Cambridge is home to the following platform technologies: Global Discovery Chemistry, Functional Genomics, Developmental & Molecular Pathways, and Models of Disease Center.In order to attract and develop an exceptionally talented and committed staff, Novartis Institutes for BioMedical Research offers an innovative and comprehensive benefits package, including healthcare, insurance, savings, retirement, and work/life benefits.We are seeking an experienced scientist to lead a Biochemical & Molecular Toxicology Laboratory within Investigative Toxicology (Preclinical Safety, Exploratory Development) based in Cambridge, MA. Investigative Toxicology is using non-clinical innovative investigations to discover the mechanisms of target organ toxicity and to prevent and solve pre-clinical and clinical drug safety issues. The candidate will be responsible for the design and set-up of new experimental facilities and the subsequent development, implementation and management of experimental studies. The primary deliverable of this laboratory will be to facilitate the early identification and characterisation of toxicities during preclinical phases of drug development with a particular focus on NIBR disease areas, expertise and technologies in Cambridge. In addition, the candidate will also work closely with Preclinical Safety colleagues as a part-time Project Team Representative to help assess potential safety liabilities associated with novel drugs and their target(s). The candidate will report to the Global Head of Molecular Toxicology and will interact closely with colleagues in other groups as a member of cross-functional and multi-disciplinary teams (including global Investigative Toxicology & Preclinical Safety departments, NIBR and external collaborators).QualificationsPh.D. degree in Biochemistry, Molecular Biology, Cell Biology or a related Biological Science. Prior experience in pharmaceutical drug development and/or toxicological sciences is required. Expertise in one or more of the following areas would be an advantage: mammalian cell culture; nucleic acid biochemistry; protein biochemistry; preclinical animal models. Experience of managing highly skilled technical staff, laboratory equipment, consumables and safety is desirable. Fluency in English (written and spoken) is a must. Flexibility and ability to work in a team, comfortable with multitasking, excellent written and oral communication skills, independent and accurate working style, ability to plan and organise effectively, willingness to take on additional responsibilities are expected. Novartis Institutes for BioMedical Research is an equal opportunity employer committed to embracing and leveraging diverse backgrounds. M/F/D/V Job ID: 41440BR